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Currently, the standard of care for CCA is cytotoxic chemotherapy, with gemcitabine and cisplatin being the most effective first-line regimen over the past decade, but despite these advances, there remains an urgent need for novel treatment approaches [4]

Eur J Immunol 40(3):824835 Kao JK, Wang SC, Ho LW, Huang SW, Chang SH, Yang RC et al (2016) Chronic iron overload results in impaired bacterial killing of THP-1 derived macrophage through the inhibition of lysosomal acidification

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Cellular uptake MB49 cells were cultured for 24 h and then treated free doxorubicin solution (1.0 g/mL), free IR780 solution (1.0 g/mL), and drug-loaded nanoparticles containing doxorubicin and IR780for 6 h