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Rights and permissions Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

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In obesity-associated insulin resistance, lactate accumulation due to impaired MCT1-mediated efflux contributes to inflammation and adipocyte dysfunction [144, 252]