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Results TDP-43 is SUMOylated in the nucleus in a context specific manner Various acute stressors including oxidative (sodium arsenite, NaAsO 2 ), hyperosmotic (D-sorbitol and sodium chloride), and heat shock have been demonstrated to induce TDP-43 mislocalization and aggregation in vitro , helping to uncover key mechanisms affected in disease[24, 58, 59]