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GH AND CARDIOVASCULAR CHANGES Extensive research has shown that adult GH deficiency (AGHD) is associated with low-grade inflammation, oxidative damage, a prothrombotic tendency, an impaired adipokine profile, subclinical left ventricular (LV) dysfunction, and metabolic syndrome (23)

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Strategies can be broadly categorized into three groups: repurposing approved drugs for immunomodulatory effects, developing new drugs against emerging metabolic targets, and modulation via dietary and microbial interventions