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Fatigue or Lightheadedness: A temporary feeling of fatigue or lightheadedness has been reported, especially during the initial days of use

Comprehensive Skin Improvements The mechanisms produce: Increased Skin Thickness Both epidermis and dermis show measurable thickening, reversing age-related thinning Improved Hydration Enhanced glycosaminoglycan production creates better moisture retention Significant Smoothing Collagen synthesis stimulation reduces wrinkle depth and surface irregularities Increased Elasticity Elastin production enhancement restores youthful bounce and firmness Improved Contrast (Evenness) Reduced hyperpigmentation and more uniform skin tone Enhanced Collagen I Production The primary structural collagen increases substantially Tightened Loose Skin Matrix remodeling restores structural support Barrier Protein Repair Protective skin barrier proteins receive restoration Photodamage Reduction Mottled hyperpigmentation shows correction Photoaging Protection Photoaging protection includes keratinocyte protection from lethal UV-B radiation and blocking UV-induced erythema without increasing UV sensitivity

(trusted non-journal) National Institutes of Health

For example, topical cholesterol tends to protect barrier-disrupted skin from UV damage, while linoleic acid (-6 polyunsaturated fat) aggravates UV damage