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Keeping regular follow-up appointments with their healthcare provider to assess treatment efficacy and adjust the regimen as needed

These polymorphisms may result in difficulty with the process of methylating B12 into its usable form

Phosphoproteomic data analysis The analysis of phosphoproteomic data was generally followed as outlined in the paper introducing PhosR 51 , which employs a multi-step framework comprising two major components: the first component is the kinaseSubstrateScore function, which evaluates a given phosphosite by integrating kinase recognition motifs and phosphoproteomic dynamics, and the second component is the kinaseSubstratePred function, which combines the scores from the first component for predicting kinase-substrate relationships using an adaptive sampling-based positive-unlabeled learning method 90

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