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persistent anhedonia, dysphoria, and insomnia mark the onset of post-acute withdrawal Weeks 2 to 24: PAWS produces intermittent cravings, mood instability, cognitive slowing, and sleep disruption

JAMA Netw Open 3(7):e2011034 2020 Robertson CC, Inshaw JRJ, Onengut-Gumuscu S, Chen WM, Santa Cruz DF, Yang H, Cutler AJ, Crouch DJM, Farber E, Bridges SL, Jr., Edberg JC, Kimberly RP, Buckner JH, Deloukas P, Divers J, Dabelea D, Lawrence JM, Marcovina S, Shah AS, Greenbaum CJ, Atkinson MA, Gregersen PK, Oksenberg JR, Pociot F, Rewers MJ, Steck AK, Dunger DB, Type 1 Diabetes Genetics Consortium, Wicker LS, Concannon P, Todd JA, Rich SS

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