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Transcriptional activation of indoleamine dioxygenase by interleukin 1 and tumor necrosis factor alpha in interferon-treated epithelial cells

Glutathione redox balance in asthma: Effect of corticosteroids Because inhaled corticosteroids are the cornerstone of treatment for persistent asthma (3), clinical studies of GSH/GSSG redox balance in subjects with asthma are frequently confounded by corticosteroid exposure since both GSH and corticosteroids exert broad anti-inflammatory effects

Furthermore, the excessive accumulation of ROS not only disrupts the process of melanin synthesis, but also destabilises, synthesises and disrupts the circulation of lipids in melanocytes, resulting in damage to the mitochondrial electron transport chain and increased ROS production, creating a vicious cycle and destroying melanocytes [19]

Thus, actual adverse effects of the formulation have to be determined to evaluate the safety profile