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The vagus nerve is especially important, providing a direct neural highway between gut and brainstem: vagal afferent fibers transmit sensory signals from intestinal receptors, while efferent fibers carry brain commands to influence gut activity [21]

Reduced carcinogenesis was also confirmed in FVB/N female mice transfected with the HER-2/neu breast cancer gene

WADA concluded that: There is compelling medical evidence that Use of THC is a risk for health, mainly neurological, that has a significant impact on the health of young individuals, a cohort which is overrepresented in Athletes. The current body of objective evidence does not support THC enhancement of physiological performance, while the potential for performance enhancement through neuropsychological effects still cannot be excluded. In consideration of the values encompassed by the Spirit of Sport as outlined by the Ethics EAG, and noting in particular that respect for self and other participants includes the safety of fellow-competitors, the Use of THC In-competition violates the Spirit of Sport. Based on these three criteria, WADA determined that THC meets the criteria to remain on the List

It is modeled after a protective protein fragment associated with gastric juice and has become a widely studied compound in preclinical research