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This is an Open Access article distributed under the terms of the CC BY license (

PMID: 18239817

Figure 7: Changes in the levels of A) IL-1-beta, B) TNF-alpha, and C) IL-10 in each of the four different experimental groups included in the first part of the study

Nevertheless, these endogenous biomarkers are present in both the tumor microenvironment and the normal microenvironment with low levels and suffer from poor specificity and low release efficiency