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doi: 10.3390/antiox11051034 Summary Keywords osteoarthritis, ferroptosis, metabolic reprogramming, immunometabolic crosstalk, iron homeostasis, lipid peroxidation, inflammatory microenvironment Citation Xia S, Li L, Shi Z, Sun N and He Y (2025) Ferroptosis in osteoarthritis: metabolic reprogramming, immunometabolic crosstalk, and targeted intervention strategies