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The National Cancer Institute conducted chemoinformatics analysis of 60 cell lines and showed a negative correlation between xCT expression levels and sensitivity to compounds associated with GSH-mediated resistance, which indicated that xCT expression induces chemoresistance via GSH-mediated ROS detoxification activity (82)

Promoting glutathione production is a direct way to reduce the oxidative duress put on cells

Under-dosing means wasted weeks waiting for results that should have arrived sooner

In the SGZ, radial glia-like or type 1 cellsadult multipotent NSPCs also exhibit a multistep differentiation process as described for the SVZ niche, beginning with the expansion of type 2a cells (transient amplifying progenitor cells) (Seri et al., 2001