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Specifically, they found that Stage B1 dogs have increased LADn, suggesting that enlargement of the left atrium (LA) already has begun in Stage B1 cavaliers, even though the ACVIM's 2019 Consensus Statement insists that Stage B1 cavaliers have normal sized LAs when in fact their LAs already have been enlarging

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Trimethylamine N-oxide promotes tissue factor expression and activity in vascular endothelial cells: a new link between trimethylamine N-oxide and atherosclerotic thrombosis

8l) which may be associated with the changes in gene expression of reactive microglia/macrophage markers in the midbrain following etomoxir treatment (Fig