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Safety is often tied to the dosage and the delivery method

M2 macrophages possess a weak antigen-presenting ability, and secrete anti-inflammatory cytokines such as IL-10 or TGF-, and down-regulate the immune response [88,89,90].Tumor-associated macrophages (TAMs) have been shown to be functionally plastic as a special type of macrophage, which are often described as M2-like population, but there is also evidence for the existence of M1-like population [91,92,93].In fact, in the early phase of tumor establishment, TAMs display an inflammatory phenotype, but an immunosuppressive phenotype is present at the later stages of tumor progression [94]

It participates in mitochondrial electron transport and can also serve as a pro-apoptotic signal if released into the cytosol

With its widespread use as a sugar substitute in over 6,000 products, from diet sodas to chewing gum, aspartame has long been a subject of scrutiny and concern