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Georgiou AC, Crielaard W, Armenis I, de Vries R, van der Waal SV (2019) Apical periodontitis is associated with elevated concentrations of inflammatory mediators in peripheral blood: a systematic review and meta-analysis

Molecular analyses performed 1 week after surgery revealed that regeneration-related genes (VEGF, BDNF, GDNF, CNTF, NGF) were significantly upregulated in the AFG/fSAP group compared to controls, suggesting a positive effect over angiogenesis, neuritogenesis, and myelination