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doi: 10.1093/jnci/53.4.1093 138 CheTCHFranoisSBouchetSChapelAForgue-LafitteM-E

NAD+/NADH ratio assays, SIRT1 activity assays, and mitochondrial respiration measurements (such as oxygen consumption rate via extracellular flux analysis) are standard methods for studying this combination's proposed effects in cell-based models, typically comparing single-compound and combined-compound treatment conditions against untreated controls

10.1111/j.1346-8138.2010.00787.x 96 HwangS

However, it is widely accepted that HO-1 is a heat shock protein that is controlled by inflammatory or pro-oxidant states and is induced in various pathologies in response to oxidative stress [1]