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Limitations of traditional mechanistic frameworks Traditional models of CVD-cognitive impairment comorbidity primarily focus on vascular-mediated processes, including cerebral hypoperfusion, where arterial stenosis or HF-induced reduction in blood flow impairs the delivery of oxygen and nutrients to neurons

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Dasatinib, a second-generation tyrosine kinase inhibitor, induces melanogenesis via ERK-CREB-MITF-tyrosinase signaling in normal human melanocytes