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2 Pathophysiology of traumatic brain injury In the United States, TBI accounts for around 40% of deaths resulting from acute injuries and stands as the primary cause of death in individuals under the age of 45

2.Intramuscular injection can cause local pain, should be deep intramuscular injection

Overall, comparison of reported K p,brain, AUC u,brain /AUC u,plasma and K p,uu,brain values for released parent drug after prodrug dosing and drug itself (Table II) revealed significant improvement of brain delivery extent after administration of the following prodruds/derivatives: L-lysine-methotrexate conjugate in mice (117), lysine derivative of ketoprofen in rats (112), phenylalanine derivatives of ketoprofen in mice (79), venlafaxine-thiamine disulfide-glucose prodrug in mice (144), glucose prodrug of ibuprofen in mice (145), ascorbic acid derivatives of ibuprofen in mice (145, 147)

[DOI] [PubMed] [Google Scholar] 47.Wang L., Bau H., Liao H., Chung K