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Prescription opioid use and risk for major depressive disorder and anxiety and stress-related disorders: a multivariable Mendelian randomization analysis

Do peptides replace hormones?+ Most peptides stimulate the body's natural hormone production rather than directly replacing hormones

4.3.4 Gamma-aminobutyric acid Gamma-aminobutyric acid (GABA), a dual-function neurotransmitter with both excitatory and inhibitory properties in the ENS, regulates gastrointestinal functions via ionotropic (GABA_A/C) and metabotropic (GABA_B) receptors, exhibiting segment-specific and receptor subtype-specific effects: in the stomach, GABA_A receptor activation mediates smooth muscle relaxation through NO release, while GABA_B receptors promote contraction by enhancing cholinergic signaling