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Key points Mitral regurgitation has generated growing interest over the past 20 years

L-Carnitine binds to these toxic byproducts, forming acylcarnitines that can be safely transported out of the mitochondria and excreted in the urine

The same dose of L-carnitine and selenium was used in the intervention group of this trial, while participants in both the intervention and control groups also received standard therapy (methimazole and beta blockers)

The intestinal absorption of heme is thought to occur through two primary mechanisms: receptor-mediated endocytosis and the direct transport of heme by heme carrier protein 1 (HCP1)