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This results in an increase in nonsynaptic glutamate, which then acts on the glutamate receptors (mGluR2/3) of presynaptic neurons

Disruptions in the Methionine Cycle A lack of folate compromises the conversion of homocysteine back to methionine, leading to several metabolic disturbances: Homocysteine Accumulation and Hyperhomocysteinemia Without sufficient folate, homocysteine levels rise, resulting in hyperhomocysteinemia, a condition linked to oxidative stress, inflammation, and metabolic stress