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380 FINO2 indirectly inhibits GPX4 activity (unlike Erastin and RSL3) without depleting GPX4 protein (unlike FIN56), while also oxidizing iron to drive ferroptosis

The results confirmed that 120 mM NaCl interrupted iron homeostasis to increase Fe 2+ levels (Figure 1) and induced lipid peroxidation, thus corroborating that hyperosmolarity activated corneal epithelial ferroptosis in vitro in an iron-dependent manner