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Binding of AngII to its AT1 receptor leads to the activation of MAP kinases, phosphorylation of tyrosine kinases and production of ROS, all of which induce VSMC proliferation

(5) Preclinical assessment: Thorough preclinical evaluation of nanomaterials in relevant animal models and in vitro assays is essential to identify and address potential safety concerns before progressing to clinical trials [341]

mutations R564C, V566A, G650E), UKNP2.1.1 (KU285220.1), AMS2b (KR094963.1), AMS3a (KR094964.1), UKNP4.1.1 (ALV85530.1), UKNP5.2.1 (ALV85536.1), and UKNP6.1.2 (ALV85538.1)