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In the initial phase, univariate Mendelian randomization (UVMR) was employed to evaluate the causal relationship between uric acid levels and various renal diseases, utilizing single nucleotide polymorphisms (SNPs) as instrumental variables for each exposure

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In this review, we discuss intracellular sources of ROS, the role of oxidative stress in heart disease, evidence linking mitochondrial ROS to cardiac disease, the efficacy of ROS-based therapeutics in the heart, and the emerging frontier of mitochondria-targeted antioxidant therapies and their application to cardiac disease