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In SURPASS-4, tirzepatide 5, 10 and 15 mg reduced triglycerides, low-density lipoprotein cholesterol (LDL-C) and total cholesterol, and increased HDL-C, compared with baseline and the active comparator in the high CV risk population (82% on lipid-lowering therapy at baseline, which was continued throughout the study) [11]

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Instead, driven by supersaturation, they spontaneously form oligomers through intermolecular hydrogen bonds and - stacking, subsequently assembling into nanoscale molecular aggregates

Stevens-Johnson Syndrome: A rare allergic reaction to certain drugs which can result in painful rash and blisters and can potentially be life-threatening