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Glutathione decreases in dopaminergic PC12 cells interfere with the ubiquitin protein degradation pathway: Relevance for Parkinsons disease

During the process of research & development, imipramine was synthesized as a structural analog of chlorpromazine

then the supernatant from lysed cells was incubated at room temperature for 23 h in a 96-well microplate precoated with monoclonal antibodies to complexes I, II, or IV