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[5] [6] Since glutathione, ascorbate and NADPH are present in high concentrations in plant cells it is assumed that the glutathione-ascorbate cycle plays a key role for H 2 O 2 detoxification

Additionally, over 80% of GSH molecules are concentrated in the cytosol, while other organelles contain lower amounts (~10%)

Many initial responders eventually experience relapse, a process driven by tumor immunoediting under therapeutic pressure, which disrupts the induction and maintenance of AIM