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Description

How the human protocols are structured: Onetime gene transfer dosing (not daily injections) IM injection sites distributed through target muscles Followup over months for functional endpoints Dosing Protocol (Human clinical data only) Protocol A Becker Muscular Dystrophy (Doseescalation cohorts) Low cohort: 6 10 vg/kg total (IM

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NADPH is produced through the pentose phosphate pathway (PPP) (Figure 1E, Supplemental Figure 3A)

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Avoid placing the vial in the fridge door, as this area experiences frequent temperature fluctuations from opening and closing

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