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The knockout mouse data is particularly useful for interpreting this: long-term AOD-9604 treatment in beta3-AR-deficient mice failed to produce body weight reduction or sustained lipolysis, confirming that the chronic fat loss effect depends on this receptor pathway

Injectable forms offer more predictable pharmacokinetics but carry compounding complexity and patient compliance barriers

Chondroprotective potential of AOD9604 in cartilage degradation models. Arthritis Res Ther

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