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General Features of ATB 0,+ (SLC6A14) ATB 0,+ is a plasma membrane transporter belonging to the SLC6 family that includes amino acid transporters, neurotransmitter transporters, and osmolyte transporters (Pramod et al., 2013)

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In summary, the accumulation of TMAO will not only increase oxidative stress and endothelial cell damage and permeability but also lead to an increase endothelial-derived NOS expression ( Vascular Calcification: TMAO Activates the NLRP3 Inflammasome and NF-B Signaling Pathway in Vascular Smooth Muscle Cells (VSMCs) Vascular calcification (VC) is a phenomenon of disseminated deposition of mineral content within the medial layer of arteries