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Additionally, ketamine activates the NLRP3 inflammasome, inducing caspase-1 activation and neuronal pyroptosis, further contributing to neuroinflammation in regions, such as the hippocampus and prefrontal cortex (Zhang et al., 2021)

It describes what must happen in tissue for recovery to become durable

Cell 74 , 185195 (1993)

Also observed was a thickened perineurium, an epineurium with abundant angiogenesis at the site of suture, and foreign body giant cells without granulomas, with an inflammatory infiltrate of lymphocytes