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The biotransformation of oxaliplatin from reactions with cysteine, glutathione, and methionine at physiological pH has shown that oxaliplatin complexes could be formed via direct displacement of the labile leaving ligand without prior aquation 31,32

Biotinylation of the newly-formed protein free-thiols provides the basis for visualization using streptavidin-based colorimetric or fluorescence detection

"Assessment of the Ability of a Fourth-Generation Immunoassay for Human Immunodeficiency Virus (HIV) Antibody and P24 Antigen Detect Both Acute and Recent HIV Infections in a High-Risk Setting." J Clin Microbiol 47.8 (2009): 2639-42