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Amantadine as treatment for dyskinesias and motor fluctuations in Parkinsons disease

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The review found that oral and topical formulations demonstrate significant but variable melanin reduction with minimal side effects, while intravenous glutathione carries serious safety concerns including anaphylaxis and hepatotoxicity

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The untargeted metabolomics experiments revealed that GTN affects several important metabolic pathways involved in maintaining redox homeostasis, amino acid metabolism, and purine metabolism ( Figure 3 )

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