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Another effect of aging is capillary loss, accompanied by a decline in SIRT1 activity and NAD + levels

Ventura E, Ducci G, Benot Dominguez R, Ruggiero V, Belfiore A, Sacco E, Vanoni M, Iozzo RV, Giordano A, Morrione A

(3) transport of fatty acids across the muscle cell membrane and within the cell cytosol

Nuclear factor erythroid 2-related factor 2 plays a fundamental role in the response to oxidative stress and xenobiotic metabolism and detoxification, and the Nrf2 signaling pathway is intimately associated with development of atherosclerosis