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10.1037/a0033325 80

When a CpG island in the promoter region of a gene is methylated, expression of the gene is repressed (it is turned off)

Oxidative stress plays a role in all of these chronic conditions, and decreased SOD1 (or too much ROS) can contribute to the development of these diseases.[ref][ref] Oxidative stress seems to play a role in Alzheimers disease as well, and SOD1 variants have been studied to see if they affect the risk of Alzheimers

This suppression indirectly reduces the recruitment of plasmacytoid dendritic cells (pDCs) and the activation of interferon pathways ( Clostridium leptum, while reducing the proportion of the Bacteroidetes phylum