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"The emergence of major cellular processes in evolution"

F.ThipakornY.AlgonA

Specifically, dysregulated neuronal energy metabolism can trigger apoptotic cascades via mitochondrial membrane potential collapse or abnormal pyruvate dehydrogenase complex phosphorylation, while targeting monocarboxylate transporter MCT2-mediated lactate shuttling or mitochondrial calcium uniporter (MCU) activity has emerged as a promising therapeutic strategy for neurodegenerative disorders