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Finally, low glutamine in the core region of solid tumors led to histone hypermethylation due to decreased -ketoglutarate level, resulting in cell dedifferentiation and therapeutic resistance in melanoma cells [64]

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Pre-treatment with GnRHa or ulipristal acetate prior to laparoscopic and laparotomic myomectomy: A systematic review and meta-analysis

Conversely, pharmacological inhibition of FSP1 or DHODH can sensitize tumors to ferroptosis, especially in cancers with high FSP1 expression or reliance on mitochondrial metabolism, raising the possibility of synthetic lethality when combined with GPX4 inhibition