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Inflammatory cytokines, such as TNF, IFN-, and IL-6, impair HSC self-renewal and differentiation, leading to accelerated aging and depletion of the HSC pool

Of note, we performed this analysis in 3 independent human cell lines expressing mitotags that enable immunopurification of mitochondria and identification of mitochondrial metabolites whose abundance changes upon SLC25A39 loss 15

At the molecular level, feeding during the inactive phase has been shown to abolish the daily rhythm in skeletal muscle mitochondria respiration (de Goede et al., 2022)