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doi: 10.1038/sigtrans.2017.23 213 BaiXFeldmanNEChmuraKOvrutskyARSuWLGriffinLet al

The FGF19 subfamily of FGFs, consisting of FGF19, FGF21, and FGF23, is characterized by reduced affinity for heparan sulfate (HS) ( via the systemic circulation, as well as canonical FGF paracrine signaling on their cell of origin or nearby cells ( This review examines the unique physiology of FGF21 signaling at the cellular, tissue, and whole-body level, presenting preclinical and clinical evidence that FGF21-based therapeutics exert a broad set of metabolic actions and also suppress inflammation and fibrosis

T2* CMRI is a crucial marker for diagnosing and monitoring iron chelation therapy in IOC patients, significantly improving the survival of -thalassemia major (-TM) (98100)