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In the Arabidopsis ASC synthesis mutant vtc1 , the activity of the ASC synthesis key enzyme GDP-mannose phosphorylase is impaired, causing it to have only about 30% ASC of that in the wild type

The prevalence and overlap of interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome in men: results of the RAND Interstitial Cystitis Epidemiology male study