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The symptoms affect each patient differently and they may not notice each stages symptoms

doi: 10.1016/j.dld.2018.09.017 179 ZhuX.TangW.FanZ.SunS.TanX

Long term daily use of 10mg or more of vitamin B6 may lead to mild tingling and numbness

Clinically, knowledgeable providers may explore off-label pharmaceutical treatments such as Low Dose Naltrexone (LDN), which has shown significant promise in modulating microglial activation