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Metabolic resistance represents the most potent and widespread mechanism by which insect pests evade insecticide toxicity. Unlike target site resistance, it confers broad spectrum cross resistance across multiple chemical classes simultaneously. This Toxicity of Glutathione Binding Metals: A Review of Targets and Mechanisms PMC The Selenoprotein Glutathione Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities PMC Current Insights into the Molecular Mechanisms of Arsenic Tolerance in Wheat (Triticum aestivum L.) and Comparisons with Other Cereals Journal of Plant Growth Regulation Springer Nature Link
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