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These data suggest that altered pre-adipocyte mesenchymal stem cells, adipogenesis and energy metabolism are important in development of MSL fat

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Abbreviations CaOx: Calcium oxalate EZH2: Enhancer of zeste homolog 2 PRC2: Polycomb repressive complex 2 H3K27me3: Trimethylation of histone H3 lysine 27 SLC7A11: Solute carrier family 7, member 11 SLC3A2: Solute carrier family 3, member 2 GPX4: Glutathione peroxidase 4 ACSL4: Acyl-CoA synthetase long-chain family4 PTGS2: Prostaglandin-endoperoxide synthase 2 AKI: Acute kidney injury CKD: Chronic kidney disease TEC: Tubular epithelial cell RCD: Regulated cell death ROS: Reactive oxygen species GSH: Glutathione MDA: Malondialdehyde BUN: Blood urea nitrogen Cr: Creatinine IHC: Immunohistochemistry TEM: Transmission electron microscopy CHIP: Chromatin immunoprecipitation Gly: Glyoxylic CD31: Platelet endothelial cell adhesion molecule-1 SMA: Alpha smooth muscle Actin E-cad: E-cadherin References Zeng G, et al