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This approach balances therapeutic benefits against theoretical concerns about long-term continuous use, for which we lack human safety data

More recently, in view of the drawbacks of 4cB12, refined models have been developed based on "missing" biomarkers

Drugs such as carvedilol, lidocaine, propafenone, and verapamil exhibit reduced clearance and prolonged half-life, necessitating dose reductions of 23 fold in moderate to severe liver disease (11)