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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

Matte, J.J., A

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178 Compared with traditional single-target agents, SIRT1 activators simultaneously modulate several critical pathways, including metabolism, immune responses, and oxidative balance, offering a network reprogramming therapeutic advantage, particularly in the early stages of the disease when multiple processes are synergistically dysregulated