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These groups include: Vegetarians and Vegans: Because plant-based diets lack natural sources of B12, supplementation is often necessary to prevent deficiency-related symptoms such as fatigue, anaemia, and nerve damage

In some embodiments, the invention encompasses a method of providing muscular therapy by co-administering a therapeutically effective amount of one or more NNMT inhibitors with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that increase intracellular NAD+ levels to provide muscular therapy

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