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Integrating circadian biology into clinical practice thus adds a multidirectional perspective: the circadian system influences aging, is influenced by it, and critically modulates therapeutic efficacy and safety

Studies have demonstrated significant HbA1c reductionoften greater than two percentage pointsalongside substantial weight loss outcomes

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Addressing instability, PK variability, biomarker gaps, and ecological uncertainty through standardized, biomarker-driven, and context-specific approaches will be essential to bridge the gap between experimental promise and responsible pharmacological application