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Extracellular HSP70 binding to surface receptors present on antigen presenting cells and endothelial/epithelial cells

ART Assisted Reproductive Technology WHO world Health Organization IVF Invitro Fertilization ICSI Intracytoplasmic sperm injection EDC Endocrine disrupting chemicals HPG Hypothalamic Pituitary Gonadal PM Particulate Matter PAH Polycyclic aromatic hydrocarbon ROS Reactive oxygen species TNF Tumor Necrosis factor IL Interleukin NF Necrosis factor LH Luteinizing hormone FSH Follicle-Stimulating hormone AQLI Air quality life index O ozone CO Carbon monoxide NO Nitrogen dioxide Cd Cadmium Pb Lead Cr Chromium Hg Mercury PVC Polyvinyl chloride AAS Atomic absorption spectroscopy F-AAS Flame Atomic absorption spectroscopy ASPR Age standardized Prevalence rate ICP MS -Inductively coupled mass spectroscopy MP Microplastics TFL Thermal Fertility Limit CTL Critical temperature limit TWAS transcriptome-wide association study GWAS genome-wide association study eQTL expression quantitative trait locus

NNMT protein expression in muscle tissue was significantly greater in aged (27-mo old C57BL/6 mice) compared to young (3-mo old C57BL/6 mice) individuals ( FIG

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