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Reported issues, usually mild, include redness, itching, or contact sensitivity, particularly when GHK-Cu is combined with strong actives like retinoids or exfoliating acids

This observation can potentially change the current situation, where patients with type 2 DM take antidiabetic medication for lifetime

[4] The proposed mechanism of action, based only on preclinical animal studies, involves potential modulation of growth factor pathways, particularly vascular endothelial growth factor (VEGF), which may promote angiogenesisthe formation of new blood vessels

Its small molecular size allows reasonable skin penetration, making it one of the few peptides with practical topical applications in dermatological research