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Once inside cells, intracellular thioesterases rapidly hydrolyze the acetyl group, releasing biologically active reduced glutathione

Liu L, Fu Q, Ding H, Jiang H, Zhan Z, Lai Y

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However, studies in mice show NR is more effectively taken up than NMN in some tissues, such as skeletal muscle 39 , highlighting the importance of the choice of precursor treatment depending on the intended target organ